从遗传学和结构角度深入了解 DEG/ENaC 通道门控。
Insight into DEG/ENaC channel gating from genetics and structure.
机构信息
Department of Molecular and Cellular Physiology, Stanford University, Stanford, California, USA.
出版信息
Physiology (Bethesda). 2012 Oct;27(5):282-90. doi: 10.1152/physiol.00006.2012.
Abstract
The founding members of the superfamily of DEG/ENaC ion channel proteins are C. elegans proteins that form mechanosensitive channels in touch and pain receptors. For more than a decade, the research community has used mutagenesis to identify motifs that regulate gating. This review integrates insight derived from unbiased in vivo mutagenesis screens with recent crystal structures to develop new models for activation of mechanically gated DEGs.
摘要
该超家族的创始成员 DEG/ENaC 离子通道蛋白是线虫蛋白，在触觉和痛觉感受器中形成机械敏感通道。十多年来，研究人员一直使用诱变来鉴定调节门控的模体。这篇综述综合了来自无偏置体内诱变筛选的见解和最近的晶体结构，为机械门控 DEG 的激活开发新的模型。
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