Department of Biochemistry & Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033-0850, USA.
Acta Biochim Biophys Sin (Shanghai). 2013 Feb;45(2):71-9. doi: 10.1093/abbs/gms084. Epub 2012 Sep 30.
Traditionally, signaling pathways have been perceived to act in an autonomous manner to regulate tissue morphology, size, differentiation, and development. Recent evidence suggests that these pathways often intersect and regulate one another to elicit an appropriate response to a complex set of stimuli. Two pathways known to be important for development, growth, and homeostasis are the Wnt/β-catenin and the Hippo/YAP pathways. Growing data indicate that these two pathways influence each other in a number of ways to properly regulate tissue growth and repair. Deregulation of these pathways often contributes to tumorigenesis. In this review, we will discuss the points of intersection between the Wnt/β-catenin and Hippo/YAP pathways and how these interactions contribute to homeostasis, organ repair, and tumorigenesis.
传统上，信号通路被认为是自主作用的，以调节组织形态、大小、分化和发育。最近的证据表明，这些途径经常交叉并相互调节，以对一组复杂的刺激产生适当的反应。有两条已知对发育、生长和内稳态很重要的途径是 Wnt/β-catenin 和 Hippo/YAP 途径。越来越多的证据表明，这两条途径以多种方式相互影响，以正确调节组织生长和修复。这些途径的失调常常导致肿瘤发生。在这篇综述中，我们将讨论 Wnt/β-catenin 和 Hippo/YAP 途径之间的交汇点，以及这些相互作用如何有助于维持内稳态、器官修复和肿瘤发生。
