Lu Feizhou, Jiang Jianyuan, Zhang Fan, Xia Xinlei, Wang Lixun, Ma Xiaosheng
Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China.
Orthopedics. 2012 Oct;35(10):e1571-5. doi: 10.3928/01477447-20120919-33.
Spinal gout is rare in patients younger than 45 years, occurring most commonly between ages 45 and 80 years. This article describes a 29-year-old man with a history of gout initially observed more than 20 years previously who presented with lower back pain and left lower limb weakness. Computed tomography and magnetic resonance imaging revealed severely damaged facet joints and laminae surrounding L4-S1, and materials with a granular, yellow, cheese-like appearance were observed under direct vision. Postoperative histological examination confirmed spinal gout. Complete posterior decompression was performed concurrently with interbody fusion at L4-L5 and L5-S1. Seventeen-month follow-up revealed good recovery.The mechanism by which urate crystals form preferentially in the spine as opposed to more common soft tissue sites is not well understood. Most reported spinal gout cases were located at L4-S1, which were believed to be the segments with high stresses. These cases occurred in older patients with degenerative spinal diseases and had trauma as indicators. The current authors presume that gout is more likely to exist in the mobile regions with high pressure, such as L4-S1, even in individuals with an initially healthy spine, especially with a long period of abnormal renal dysfunction. Although it is often overlooked in young patients, this condition may be more common than the literature suggests due to the high potential for misdiagnosis in relatively young patients.
脊柱痛风在45岁以下患者中较为罕见,最常见于45至80岁之间。本文描述了一名29岁男性,有痛风病史,最初在20多年前被发现,此次因下背部疼痛和左下肢无力就诊。计算机断层扫描和磁共振成像显示L4 - S1周围的小关节和椎板严重受损,直视下可见呈颗粒状、黄色、奶酪样外观的物质。术后组织学检查确诊为脊柱痛风。同时在L4 - L5和L5 - S1进行了椎间融合及完全后路减压。17个月的随访显示恢复良好。与更常见的软组织部位相比,尿酸盐晶体优先在脊柱中形成的机制尚不清楚。大多数报道的脊柱痛风病例位于L4 - S1,据信这些节段应力较高。这些病例发生在患有退行性脊柱疾病的老年患者中,且有创伤作为指标。本文作者推测,即使在最初脊柱健康的个体中,尤其是在长期存在异常肾功能不全的情况下,痛风更有可能存在于高压的活动区域,如L4 - S1。尽管在年轻患者中常被忽视,但由于相对年轻患者误诊的可能性很高,这种情况可能比文献报道的更为常见。