Umemura T, Sai K, Takagi A, Hasegawa R, Kurokawa Y
Division of Toxicology, National Institute of Hygienic Sciences, Tokyo, Japan.
Carcinogenesis. 1990 Feb;11(2):345-7. doi: 10.1093/carcin/11.2.345.
A significant increase of 8-hydroxydeoxyguanosine (8-OH-dG) was observed in the kidney DNA of rats given a renal carcinogen, the ferric complex of nitrilotriacetate (Fe-NTA) by single i.p. injection. By contrast, non- or weakly carcinogenic compounds, aluminum-nitrilotriacetate complex (Al-NTA), non-complexed NTA (Na2NTA) and ferric chloride had no effect on 8-OH-dG production in the kidney DNA. These results suggest the involvement of active oxygen radicals in Fe-NTA carcinogenesis.
通过单次腹腔注射给予大鼠肾致癌物次氮基三乙酸铁络合物（Fe-NTA）后，在大鼠肾脏DNA中观察到8-羟基脱氧鸟苷（8-OH-dG）显著增加。相比之下，非致癌或弱致癌化合物，次氮基三乙酸铝络合物（Al-NTA）、未络合的NTA（Na2NTA）和氯化铁对肾脏DNA中8-OH-dG的产生没有影响。这些结果表明活性氧自由基参与了Fe-NTA致癌作用。
