Sugaya N, Kanno T, Nirasawa M, Mitamura K, Takeuchi Y, Osano M
Department of Pediatrics, Nippon Kokan Hospital, Kanagawa, Japan.
Clin Chem. 1990 Feb;36(2):304-6.
In three pediatric patients with necrotizing lymphadenitis, cytosol aminopeptidase activity (c-AP; EC 3.4.11.1) in serum was markedly increased to 509, 417, and 191 U/L, respectively (normal range 25-60 U/L). Lactate dehydrogenase (LD; EC 1.1.1.27) was also increased, with LD-3 predominating. The increased concentrations of c-AP and LD presumably originated from the destruction of infected, activated lymphocytes, especially T lymphocytes. Necrotizing lymphadenitis is probably caused by a lymphocytotropic virus.
在3例坏死性淋巴结炎的儿科患者中，血清中的胞质氨基肽酶活性（c-AP；EC 3.4.11.1）分别显著升高至509、417和191 U/L（正常范围25 - 60 U/L）。乳酸脱氢酶（LD；EC 1.1.1.27）也升高，以LD-3为主。c-AP和LD浓度的升高可能源于受感染、活化淋巴细胞尤其是T淋巴细胞的破坏。坏死性淋巴结炎可能由亲淋巴细胞病毒引起。
