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绵羊模型中腰椎间盘的外侧手术入路

Lateral surgical approach to lumbar intervertebral discs in an ovine model.

作者信息

Oehme David, Goldschlager Tony, Rosenfeld Jeffrey, Danks Andrew, Ghosh Peter, Gibbon Anne, Jenkin Graham

机构信息

The Ritchie Centre, Monash Institute of Medical Research-MIMR, Monash University, Clayton, VIC 3168, Australia.

出版信息

ScientificWorldJournal. 2012;2012:873726. doi: 10.1100/2012/873726. Epub 2012 Sep 17.

DOI:10.1100/2012/873726
PMID:23028255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3458268/
Abstract

The sheep is becoming increasingly used as a large animal model for preclinical spine surgery studies. Access to the ovine lumbar intervertebral discs has traditionally been via an anterior or anterolateral approach, which requires larger wound incisions and, at times, significant abdominal retraction. We present a new minimally invasive operative technique for a far-lateral approach to the ovine lumbar spine that allows for smaller incisions, excellent visualisation of intervertebral discs, and minimal abdominal retraction and is well tolerated by animals with minimal morbidity.

摘要

绵羊越来越多地被用作临床前脊柱手术研究的大型动物模型。传统上,进入绵羊腰椎间盘是通过前路或前外侧入路,这需要更大的伤口切口,有时还需要显著的腹部牵拉。我们提出了一种新的微创外科技术,用于绵羊腰椎远外侧入路,该技术切口更小,椎间盘可视化良好,腹部牵拉最小,动物耐受性良好,发病率极低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d75/3458268/e3b2bd9c2960/TSWJ2012-873726.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d75/3458268/41fcc6731554/TSWJ2012-873726.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d75/3458268/e6bcdaf75108/TSWJ2012-873726.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d75/3458268/3cc3f4a89206/TSWJ2012-873726.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d75/3458268/7e123e34ccaa/TSWJ2012-873726.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d75/3458268/e3b2bd9c2960/TSWJ2012-873726.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d75/3458268/41fcc6731554/TSWJ2012-873726.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d75/3458268/e6bcdaf75108/TSWJ2012-873726.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d75/3458268/3cc3f4a89206/TSWJ2012-873726.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d75/3458268/7e123e34ccaa/TSWJ2012-873726.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d75/3458268/e3b2bd9c2960/TSWJ2012-873726.005.jpg

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Immunoselected STRO-3+ mesenchymal precursor cells and restoration of the extracellular matrix of degenerate intervertebral discs.免疫选择的 STRO-3+间充质前体细胞和退变椎间盘细胞外基质的修复。
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Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration.
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Global Spine J. 2018 Dec;8(8):847-859. doi: 10.1177/2192568218779988. Epub 2018 Jun 10.
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