Ludtka Christopher, Schwan Stefan, Friedmann Andrea, Brehm Walther, Wiesner Ingo, Goehre Felix
Fraunhofer Institute for Microstructure of Materials and Systems IMWS, Halle (Saale), Germany.
Department of Chemical and Biomolecular Engineering, University of Tennessee Knoxville, Knoxville, TN, USA.
Eur Spine J. 2017 Aug;26(8):2031-2037. doi: 10.1007/s00586-017-5024-8. Epub 2017 Mar 13.
The primary goal of this study is to clearly define and evaluate new intervertebral disc height parameters in analysing the morphological pathology of disc degeneration for application in damage model and regeneration therapy development, as well as applying traditional variables to 3-D characterization methods.
A posterolateral surgical approach was used to induce disc degeneration in an ovine model. At 12-months post-operation, sheep vertebral segments were removed and characterized using micro-CT to evaluate disc height parameters in regard to injury localization.
Statistically significant differences between the disc height loss of the left and right side of the disc, consistent with the lateral surgical approach used were seen using the modified average disc height method by Dabbs et al. However, convexity index and the newly proposed Cross Tilt Index did not conclusively demonstrate a difference.
Two-dimensional morphological evaluations can be applied in 3-D to provide a more complete picture of disc height loss for injury models. New 3-D parameters that are tailored to the type of surgical approach used should be investigated, with the 9-point system described herein providing a useful basis for derived values. Additionally, the surgical approach chosen when artificially injuring the disc can result in asymmetrical degeneration, as indicated by uneven disc height loss.
本研究的主要目标是明确界定并评估新的椎间盘高度参数，用于分析椎间盘退变的形态病理学，以应用于损伤模型和再生治疗的开发，并将传统变量应用于三维表征方法。
采用后外侧手术入路在绵羊模型中诱导椎间盘退变。术后12个月，取出绵羊椎体节段，使用微型计算机断层扫描（micro-CT）进行表征，以评估与损伤定位相关的椎间盘高度参数。
使用达布斯等人的改良平均椎间盘高度方法，观察到椎间盘左右两侧的椎间盘高度损失存在统计学上的显著差异，这与所采用的外侧手术入路一致。然而，凸度指数和新提出的交叉倾斜指数并未明确显示出差异。
二维形态学评估可应用于三维，为损伤模型的椎间盘高度损失提供更完整的情况。应研究针对所采用手术入路类型定制的新三维参数，本文所述的九点系统为导出值提供了有用的基础。此外，如椎间盘高度损失不均匀所示，人工损伤椎间盘时选择的手术入路可导致不对称退变。
