Cheminat A, Stampf J L, Benezra C
Arch Dermatol Res. 1984;276(3):178-81. doi: 10.1007/BF00414016.
Two methods, using methylenelactone dimethylamino adducts, were used to remove selectively alpha-methylene gamma-butyrolactones from Laurus nobilis L. extracts. Isolated lactones were identified and "treated" extracts recovered. Two guinea-pig groups were sensitized to crude extracts and "treated" extracts, respectively, and tested with primary sensitizer and with different lactones. Only the first group showed strong skin reactions to crude extracts and to the lactones. Treated extracts were shown to be anallergic.
采用两种使用亚甲基内酯二甲基氨基加合物的方法，从月桂叶提取物中选择性去除α-亚甲基γ-丁内酯。对分离得到的内酯进行了鉴定，并回收了“处理过”的提取物。将两组豚鼠分别对粗提取物和“处理过”的提取物进行致敏，并用初级致敏剂和不同的内酯进行测试。只有第一组对粗提取物和内酯表现出强烈的皮肤反应。结果表明，处理过的提取物无变应原性。
