Emergency Department, Chun'an First People's Hospital, Zhejiang Provincial People's Hospital Chun'an Branch, Hangzhou 311700, Zhejiang Province, China.
Key Laboratory of Tumor Molecular Diagnosis & Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.
Regen Med. 2020 May;15(5):1637-1645. doi: 10.2217/rme-2019-0135. Epub 2020 Jun 18.
Biomaterials dominate the field of cardiovascular therapeutics, a multitude of which have been used to repair and replace injured heart tissue. This field has evolved beyond the simple selection of compatible materials and now focuses on the rational design of controlled structures that integrate with the cardiovascular system. However, the compatibility of these materials with the blood presents a major limitation to their clinical application. In this context, surface modification strategies can enhance blood compatibility and several recent advances in this area have emerged. This review summarizes the recent applications of biomaterials in cardiovascular therapies, the improvements in their biocompatibility and the surface modification technologies that have the potential to improve clinical outcomes.
生物材料在心血管治疗领域占据主导地位，许多生物材料已被用于修复和替代受损的心脏组织。这一领域的发展已经超越了简单选择相容材料的阶段，现在专注于设计与心血管系统相整合的可控结构的合理方案。然而，这些材料与血液的相容性是其临床应用的主要限制。在这种情况下，表面改性策略可以提高血液相容性，该领域最近出现了一些进展。本文综述了生物材料在心血管治疗中的最新应用、其生物相容性的改善以及具有改善临床效果潜力的表面改性技术。
