Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seocho-Gu, Seoul, Korea.
Ocul Immunol Inflamm. 2012 Oct;20(5):360-4. doi: 10.3109/09273948.2012.709576.
To evaluate the changes in intraocular cytokine after intravitreal bevacizumab (IVB) for uveitic cystoid macular edema (CME).
The authors evaluated 9 eyes of 8 patients who underwent IVB for uveitic CME. The aqueous humor-levels of vascular endothelial growth factor (VEGF), interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β(2)were measured using suspension array technology at baseline and 1 month after IVB.
The VEGF level was decreased to insignificant level (p = .008). TGF-β(2) and TNF-α levels increased significantly (p = .008 and .021, respectively). IL-6 and IL-8 showed no significant change (p = .051 and.110, respectively).
IVB resulted in a significant decrease of VEGF levels, which was associated with anatomical improvement of CME at 1 month. Compensatory elevations of proinflammatory cytokines (IL-6 and IL-8) after selective VEGF inhibition were not observed. Marked elevation of TGF-β(2) after IVB seems to play an immunosuppressive role.
评估玻璃体内注射贝伐单抗（IVB）治疗葡萄膜炎性囊样黄斑水肿（CME）后眼内细胞因子的变化。
作者评估了 8 例患者的 9 只眼，这些患者因葡萄膜炎性 CME 而行 IVB 治疗。在基线和 IVB 治疗后 1 个月时，使用悬浮阵列技术测量房水中血管内皮生长因子（VEGF）、白细胞介素（IL）-6、IL-8、肿瘤坏死因子（TNF）-α和转化生长因子（TGF）-β2 的水平。
VEGF 水平显著降低（p=0.008）。TGF-β2 和 TNF-α水平显著升高（p=0.008 和.021，分别）。IL-6 和 IL-8 没有明显变化（p=0.051 和.110，分别）。
IVB 导致 VEGF 水平显著降低，这与 CME 在 1 个月时的解剖学改善相关。在选择性 VEGF 抑制后，促炎细胞因子（IL-6 和 IL-8）的代偿性升高并未观察到。IVB 后 TGF-β2 的明显升高似乎发挥了免疫抑制作用。
