Mulvihill Erin E, Huff Murray W
Vascular Biology, Robarts Research Institute, London, Ontario, Canada.
Cardiovasc Hematol Disord Drug Targets. 2012 Dec;12(2):84-91. doi: 10.2174/1871529x11202020084.
Epidemiological studies have demonstrated that diets rich in fruits and vegetables can prevent or delay the onset of many chronic diseases including cardiovascular disease (CVD). While more current research has begun to focus on the effects of specific polyphenol compounds found in fruits and vegetables, mechanistic insights have been hampered by the multiple simultaneous effects these compounds may have on the disease process. In this article, we review the basic research studies that have evaluated the effects of citrus flavonoids to: improve dyslipidemia, normalize glucose homeostasis, prevent oxidative stress, and attenuate inflammation, which collectively have the ability to enhance metabolic health and improve CVD risk.
流行病学研究表明，富含水果和蔬菜的饮食可以预防或延缓包括心血管疾病（CVD）在内的许多慢性疾病的发生。虽然目前更多的研究已开始关注水果和蔬菜中特定多酚化合物的作用，但这些化合物可能对疾病进程产生的多种同时作用阻碍了对其作用机制的深入了解。在本文中，我们回顾了评估柑橘类黄酮作用的基础研究，这些作用包括：改善血脂异常、使葡萄糖稳态正常化、预防氧化应激以及减轻炎症，这些作用共同具有增强代谢健康和改善心血管疾病风险的能力。
