Physiology Division, Department of Zoology, Faculty of Science, Beni-Suef University, Egypt.
Metropolitan Autonomous University, Laboratory of Bioenergetics and Cellular Aging, Department of Health Sciences, Division of Health and Biological Sciences, Mexico.
Oxid Med Cell Longev. 2019 Mar 10;2019:5484138. doi: 10.1155/2019/5484138. eCollection 2019.
The prevalence of cardiovascular disease (CVD) is increasing over time. CVD is a comorbidity in diabetes and contributes to premature death. Citrus flavonoids possess several biological activities and have emerged as efficient therapeutics for the treatment of CVD. Citrus flavonoids scavenge free radicals, improve glucose tolerance and insulin sensitivity, modulate lipid metabolism and adipocyte differentiation, suppress inflammation and apoptosis, and improve endothelial dysfunction. The intake of citrus flavonoids has been associated with improved cardiovascular outcomes. Although citrus flavonoids exerted multiple beneficial effects, their mechanisms of action are not completely established. In this review, we summarized recent findings and advances in understanding the mechanisms underlying the protective effects of citrus flavonoids against oxidative stress, inflammation, diabetes, dyslipidemia, endothelial dysfunction, and atherosclerosis. Further studies and clinical trials to assess the efficacy and to explore the underlying mechanism(s) of action of citrus flavonoids are recommended.
心血管疾病 (CVD) 的患病率随着时间的推移而增加。CVD 是糖尿病的一种合并症，并导致过早死亡。柑橘类黄酮具有多种生物活性，已成为治疗 CVD 的有效治疗方法。柑橘类黄酮能清除自由基，改善葡萄糖耐量和胰岛素敏感性，调节脂代谢和脂肪细胞分化，抑制炎症和细胞凋亡，改善内皮功能障碍。摄入柑橘类黄酮与改善心血管结局有关。尽管柑橘类黄酮发挥了多种有益作用，但它们的作用机制尚未完全确定。在这篇综述中，我们总结了最近关于柑橘类黄酮对抗氧化应激、炎症、糖尿病、血脂异常、内皮功能障碍和动脉粥样硬化的保护作用的机制的研究进展。建议进一步研究和临床试验来评估柑橘类黄酮的疗效，并探索其作用机制。
