Department of Neurosurgery, University of Florida, Box 100265, Gainesville, FL 32610, USA.
Future Oncol. 2012 Sep;8(9):1149-56. doi: 10.2217/fon.12.111.
The development of novel therapies, imaging techniques and insights into the processes that drive growth of CNS tumors have allowed growing enthusiasm for the treatment of CNS malignancies. Despite this energized effort to investigate and treat brain cancer, clinical outcomes for most patients continue to be dismal. Recognition of diverse tumor subtypes, behaviors and outcomes has led to an interest in personalized medicine for the treatment of brain tumors. This new paradigm requires evaluation of the tumor phenotype at the time of diagnosis so that therapy can be specifically tailored to each individual patient. Investigating novel therapies involving stem cells, nanotechnology and molecular medicine will allow diversity of therapeutic options for patients with brain cancer. These exciting new therapeutic strategies for brain tumors are reviewed in this article.
新型治疗方法、成像技术以及对中枢神经系统肿瘤生长过程的深入了解，使得人们对中枢神经系统恶性肿瘤的治疗产生了越来越大的热情。尽管人们在努力研究和治疗脑癌方面做出了不懈的努力，但大多数患者的临床预后仍然不容乐观。不同肿瘤亚型、行为和结果的认识促使人们对脑肿瘤的个性化治疗产生了兴趣。这种新模式需要在诊断时评估肿瘤表型，以便能够根据每个患者的具体情况定制治疗方案。研究涉及干细胞、纳米技术和分子医学的新型治疗方法将为脑癌患者提供多样化的治疗选择。本文综述了脑肿瘤的这些令人兴奋的新治疗策略。
