Iida H, Fukuda S, Kawashima N, Yamazaki T, Aoki J, Tokita K, Morioka K, Takarada N, Soeda T
Division of Comparative Radiotoxicology, National Institute of Radiological Sciences, Chiba, Japan.
Jikken Dobutsu. 1990 Jan;39(1):9-19. doi: 10.1538/expanim1978.39.1_9.
Antibody titers against canine parvovirus (CPV), canine distemper virus (CDV) and infectious canine hepatitis virus (ICHV) in serum were measured in 6 beagle dams and their 38 puppies bred in our colony, in order to clarify the effects of maternally derived antibodies to antibody responses against the viruses after vaccinations in puppies. Correlation coefficient on antibody titers between puppies and dams were CPV: r = 0. 7935, CDV: r = 0.8194 and ICHV: r = 0.8105. Mean maternal antibody positive rates in 7-day-old puppies from their dams were CPV: 67%, CDV: 46% and ICHV: 45%. Mean half-lives of the maternal antibodies in puppies were estimated to be CPV: 13.5 days, CDV: 15.1 days and ICHV: 15.4 days. The antibody response against CPV vaccination in puppies was mainly observed in dogs being titers of less 1:5 and positivity was 39% (15/38 puppies) after 1st vaccination at 42 days after birth, and 82% (31/38 puppies) after 2nd vaccination at 70 days. That against CDV vaccination (at 56 days after birth) was seen highly in dogs being titers of less 1:10 and positivity was 53% (20/38). Also that against ICHV vaccination (at 56 days after birth) was seen frequently in dogs being titers of less 20 holds and the rate was 87% (33/38). From these results, it was estimated that the age when high antibody response against each vaccination could be expected in puppies might be CPV: between 40 and 69 days, CDV: between 32 and 92 days and ICHV: between 31 and 52 days, respectively.
为了阐明母源抗体对幼犬接种疫苗后针对这些病毒的抗体反应的影响，我们对本实验群体中繁殖的6只比格犬母犬及其38只幼犬血清中抗犬细小病毒（CPV）、犬瘟热病毒（CDV）和犬传染性肝炎病毒（ICHV）的抗体滴度进行了测定。幼犬与母犬之间抗体滴度的相关系数分别为：CPV：r = 0.7935，CDV：r = 0.8194，ICHV：r = 0.8105。7日龄幼犬来自母犬的母源抗体平均阳性率分别为：CPV：67%，CDV：46%，ICHV：45%。幼犬母源抗体的平均半衰期估计分别为：CPV：13.5天，CDV：15.1天，ICHV：15.4天。幼犬对CPV疫苗接种的抗体反应主要在抗体滴度小于1:5的犬中观察到，出生后42天首次接种疫苗后阳性率为39%（15/38只幼犬），70天第二次接种疫苗后为82%（31/38只幼犬）。对CDV疫苗接种（出生后56天）的抗体反应在抗体滴度小于1:10的犬中高度可见，阳性率为53%（20/38）。对ICHV疫苗接种（出生后56天）的抗体反应在抗体滴度小于20的犬中频繁可见，比例为87%（33/38）。根据这些结果，估计幼犬对每种疫苗接种有望产生高抗体反应的年龄分别为：CPV：40至69天之间，CDV：32至92天之间，ICHV：31至52天之间。
