Yi Fei, Chen Haiyan, Wang Xiang, Shi Huqing, Yi Jinyao, Zhu Xiongzhao, Yao Shuqiao
Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, China.
Neuroreport. 2012 Nov 14;23(16):963-9. doi: 10.1097/WNR.0b013e328359d1c4.
Feedback-related negativity (FRN) is an electrophysiological index associated with impulsivity. However, the age and sex effects on FRN are not well understood. Using the single-outcome gambling task, this study investigated age-related and sex-related differences between the FRN in middle and late adolescents and adults. Forty healthy adolescents (15-17 years old) and 28 healthy adults (20-25 years old) were recruited in the event-related potentials study. The electrophysiological response to gains and losses of low and high magnitude were recorded during the single-outcome gambling task. The FRN significantly delayed in middle and late adolescents compared with adults (232.875 vs. 211.714 ms). Adults are more sensitive to the magnitude of feedback (larger amounts: 50 cents vs. small amounts: 10 cents) than valence (gain: +50/10 vs. loss: -50/10). However, middle and late adolescents are neither sensitive to magnitude nor to valence. Men showed significantly more negative FRN amplitude than women both in adolescents and adults. In addition, the hostility subscore of the Buss-Perry Aggression Questionnaire was negatively correlated with FRN amplitude. The results of this study suggested that the age-related differences did exist between the FRN in adolescents and those in adults. Men require more neural activity than women to achieve similar feedback both in adolescents and adults.
反馈相关负波（FRN）是一种与冲动性相关的电生理指标。然而，年龄和性别对FRN的影响尚未得到充分了解。本研究采用单结果赌博任务，调查了青少年中后期与成年人FRN之间的年龄和性别差异。在这项事件相关电位研究中，招募了40名健康青少年（15 - 17岁）和28名健康成年人（20 - 25岁）。在单结果赌博任务期间，记录了对低幅度和高幅度得失的电生理反应。与成年人相比，青少年中后期的FRN显著延迟（232.875毫秒对211.714毫秒）。成年人对反馈幅度（较大金额：50美分对较小金额：10美分）比效价（收益：+50/10对损失：-50/10）更敏感。然而，青少年中后期对幅度和效价均不敏感。在青少年和成年人中，男性的FRN负波幅均显著高于女性。此外，布斯-佩里攻击性问卷的敌意子得分与FRN波幅呈负相关。本研究结果表明，青少年与成年人的FRN之间确实存在年龄相关差异。在青少年和成年人中，男性比女性需要更多的神经活动来获得相似的反馈。
