Briggs W L, Phelps R W, Swanson G D
Department of Mathematics, University of Colorado, Denver 80202.
IEEE Trans Biomed Eng. 1990 Jan;37(1):80-4. doi: 10.1109/10.43619.
A general probabilistic approach is applied to the single-point, single-dose method for estimating individual infusion rates and serum drug concentrations. By using transformations of probability density functions, the effects of variations in the elimination rate constant upon pharmacokinetic variables may be studied and optimal sampling times may be chosen. Although this study treats the case of error-free sampling in a single-compartment model with a normal distribution of rate constants, the methods presented can be extended to more general situations.
一种通用的概率方法应用于用于估计个体输注速率和血清药物浓度的单点、单剂量方法。通过使用概率密度函数的变换，可以研究消除速率常数变化对药代动力学变量的影响，并可以选择最佳采样时间。尽管本研究处理的是速率常数呈正态分布的单室模型中无误差采样的情况，但所提出的方法可以扩展到更一般的情况。
