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Amplitude, kinetics, and reversibility of a light-induced decrease in guanosine 3',5'-cyclic monophosphate in frog photoreceptor membranes.青蛙光感受器膜中光诱导的3',5'-环磷酸鸟苷减少的幅度、动力学及可逆性。
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Cyclic GMP releases calcium from disc membranes of vertebrate photoreceptors.环磷酸鸟苷从脊椎动物光感受器的盘膜中释放钙。
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Incorporation of a retinal rod cGMP-dependent conductance into planar bilayers.将视网膜视杆细胞环鸟苷酸依赖性电导整合到平面双层膜中。
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4
Control of the light-regulated current in rod photoreceptors by cyclic GMP, calcium, and l-cis-diltiazem.环磷酸鸟苷、钙和左旋顺式地尔硫䓬对视杆光感受器中光调节电流的控制
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8
Guanosine 3',5'-cyclic monophosphate-activated conductance studied in a truncated rod outer segment of the toad.在蟾蜍截短的视杆外段中研究的3',5'-环磷酸鸟苷激活的电导。
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本文引用的文献

1
Efflux of potassium from isolated rod outer segments: a photic effect.钾离子从离体视杆细胞外段的流出：一种光效应。
J Physiol. 1973 Aug;232(3):609-20. doi: 10.1113/jphysiol.1973.sp010288.
2
Light activation of phosphodiesterase activity in retinal rod outer segments.视网膜视杆细胞外段中磷酸二酯酶活性的光激活。
Biochim Biophys Acta. 1974 Jun 28;347(3):491-3. doi: 10.1016/0005-2728(74)90086-3.
3
Light-regulated guanosine 3',5'-monophosphate phosphodiesterase of bovine retina.牛视网膜的光调节鸟苷 3',5'-单磷酸磷酸二酯酶
Nature. 1974 Mar 1;248(5443):57-8. doi: 10.1038/248057a0.
4
Effect of strong illumination on the ion efflux from the isolated discs of frog photoreceptors.强光对离体青蛙光感受器盘离子外流的影响。
Biochim Biophys Acta. 1975 Jul 18;394(4):577-85. doi: 10.1016/0005-2736(75)90143-1.
5
On the metabolism of the rod outer segments.关于视杆细胞外段的代谢
J Physiol. 1976 Jun;257(3):687-97. doi: 10.1113/jphysiol.1976.sp011392.
6
Light-activated hydrolysis of GTP and cyclic GMP in the rod outer segments.视杆细胞外段中GTP和环鸟苷酸的光激活水解作用。
J Physiol. 1978 Jun;279:55-69. doi: 10.1113/jphysiol.1978.sp012330.
7
A light-activated GTPase in vertebrate photoreceptors: regulation of light-activated cyclic GMP phosphodiesterase.脊椎动物光感受器中的一种光激活型鸟苷三磷酸酶：光激活型环鸟苷酸磷酸二酯酶的调节
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4238-42. doi: 10.1073/pnas.74.10.4238.
8
Guanosine 3',5'-cyclic monophosphate and the in vitro physiology of frog photoreceptor membranes.3',5'-环磷酸鸟苷与蛙类光感受器膜的体外生理学
J Gen Physiol. 1977 May;69(5):667-79. doi: 10.1085/jgp.69.5.667.
9
Biochemical correlates of adaptation processes in isolated frog photoreceptor membranes.离体青蛙光感受器膜中适应过程的生化关联
J Gen Physiol. 1976 Jul;68(1):1-11. doi: 10.1085/jgp.68.1.1.
10
Light-sensitive swelling of isolated frog rod outer segments as an in vitro assay for visual transduction and dark adaptation.离体青蛙视杆细胞外段的光敏肿胀作为视觉转导和暗适应的体外测定方法。
J Gen Physiol. 1975 Oct;66(4):407-25. doi: 10.1085/jgp.66.4.407.

环鸟苷酸与青蛙光感受器盘膜的通透性

Cyclic GMP and the permeability of the disks of the frog photoreceptors.

作者信息

Caretta A, Cavaggioni A, Sorbi R T

出版信息

J Physiol. 1979 Oct;295:171-8. doi: 10.1113/jphysiol.1979.sp012959.

DOI:10.1113/jphysiol.1979.sp012959
PMID:230335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1278791/
Abstract
  1. The diffusion of sodium, potassium and rubidium (not chloride) ions across the disk membrane is increased by cyclic guanosine monophosphate (cyclic GMP). 2. The increase is greater for sodium than for rubidium in the 0.01-0.1 mM concentration range. 3. Cyclic adenosine monophosphate (cyclic AMP) is less efficient than cyclic GMP; GMP and guanosine triphosphate are without effect. 4. The effect is present with either 1.8 mM calcium ions or 4 mM-EGTA in the perfusion fluid. 5. The presence of the cyclic GMP phosphodiesterase on the disk membranes is not needed for this effect. 6. The effect is present in both unbleached and fully bleached membranes.
摘要
  1. 环磷酸鸟苷（环GMP）可增加钠、钾和铷（而非氯）离子跨盘膜的扩散。2. 在0.01 - 0.1 mM浓度范围内，钠的增加幅度大于铷。3. 环磷酸腺苷（环AMP）的效率低于环GMP；GMP和三磷酸鸟苷无作用。4. 灌注液中存在1.8 mM钙离子或4 mM乙二醇双四乙酸（EGTA）时该效应依然存在。5. 此效应不需要盘膜上存在环GMP磷酸二酯酶。6. 未漂白和完全漂白的膜中均存在该效应。