Halachev Konstantin, Bast Hannah, Albrecht Felipe, Lengauer Thomas, Bock Christoph
Genome Biol. 2012 Oct 3;13(10):R96. doi: 10.1186/gb-2012-13-10-r96.
Epigenome mapping consortia are generating resources of tremendous value for studying epigenetic regulation. To maximize their utility and impact, new tools are needed that facilitate interactive analysis of epigenome datasets. Here we describe EpiExplorer, a web tool for exploring genome and epigenome data on a genomic scale. We demonstrate EpiExplorer's utility by describing a hypothesis-generating analysis of DNA hydroxymethylation in relation to public reference maps of the human epigenome. All EpiExplorer analyses are performed dynamically within seconds, using an efficient and versatile text indexing scheme that we introduce to bioinformatics. EpiExplorer is available at http://epiexplorer.mpi-inf.mpg.de.
表观基因组图谱联盟正在生成用于研究表观遗传调控的极具价值的资源。为了最大限度地发挥其效用和影响力，需要新的工具来促进表观基因组数据集的交互式分析。在这里，我们描述了EpiExplorer，这是一个用于在基因组规模上探索基因组和表观基因组数据的网络工具。我们通过描述与人类表观基因组公共参考图谱相关的DNA羟甲基化的假设生成分析，展示了EpiExplorer的效用。所有EpiExplorer分析均在数秒内动态执行，使用了一种我们引入生物信息学的高效且通用的文本索引方案。EpiExplorer可在http://epiexplorer.mpi-inf.mpg.de获取。
