McCoy T J, Wabers H D, Cooper S L
Department of Chemical Engineering, University of Wisconsin Madison 53706.
J Biomed Mater Res. 1990 Jan;24(1):107-29. doi: 10.1002/jbm.820240110.
Well characterized, laboratory-synthesized polymeric materials which have been extensively tested for biocompatibility via initial platelet and protein deposition in an acute ex vivo canine model were placed as interpositional series shunts in canines with chronically implanted iliac arteriovenous shunts ex vivo. Platelet deposition was measured on a base polyurethane block copolymer, a sulfonated ionic derivative, an alkyl grafted (C18) derivative, Biomer, polyethylene, and polydimethylsiloxane for 24 h using radiolabeled platelets. Platelet survival and in vitro aggregation were determined to investigate the effects of the shunting procedure on experimental animals. The viability of adopting a chronic arteriovenous (iliac) shunted canine model for use with series shunts to evaluate polyurethanes having applications as materials in vascular graft construction was investigated and the results compared with acute model data.
对经过充分表征的、在急性离体犬模型中通过初始血小板和蛋白质沉积对生物相容性进行了广泛测试的实验室合成聚合物材料，在具有慢性植入的离体髂动静脉分流术的犬中作为间置式串联分流器放置。使用放射性标记的血小板，在基础聚氨酯嵌段共聚物、磺化离子衍生物、烷基接枝（C18）衍生物、Biomer、聚乙烯和聚二甲基硅氧烷上测量血小板沉积24小时。测定血小板存活率和体外聚集情况，以研究分流程序对实验动物的影响。研究了采用慢性动静脉（髂）分流犬模型与串联分流器一起用于评估具有血管移植物构建材料应用的聚氨酯的可行性，并将结果与急性模型数据进行比较。
