Keough E M, Mackey W C, Connolly R, Foxall T, Ramberg-Laskaris K, McCullough J L, O'Donnell T F, Callow A D
J Biomed Mater Res. 1985 May-Jun;19(5):577-87. doi: 10.1002/jbm.820190509.
The interaction of 111Indium-labeled platelets, and other blood components with the luminal surface of polydimethylsiloxane (PDMS) and low-density polyethylene (LDPE) was determined using an ex vivo arteriovenous shunt in the baboon. Both PDMS and LDPE showed little platelet accumulation at either high (200 cc/min) flow rates. PDMS accumulated more platelets at low than at high flow. When the surfaces of PDMS and LDPE were examined under scanning electron microscopy after 2.5 h of flow in the shunt circuit, red and white blood cells were attached. Platelets appeared to be confined to patchy areas covered by a fibrinlike network. The low platelet reactivity of LDPE and PDMS suggests their potential use as coatings for conventional, more platelet reactive vascular graft materials.
利用狒狒的体外动静脉分流装置，测定了¹¹¹铟标记的血小板及其他血液成分与聚二甲基硅氧烷（PDMS）和低密度聚乙烯（LDPE）管腔表面的相互作用。在高流速（200毫升/分钟）时，PDMS和LDPE的血小板聚集都很少。与高流速相比，PDMS在低流速时聚集的血小板更多。当在分流回路中流动2.5小时后，用扫描电子显微镜检查PDMS和LDPE的表面时，发现有红细胞和白细胞附着。血小板似乎局限于由纤维蛋白样网络覆盖的斑片状区域。LDPE和PDMS的低血小板反应性表明它们有可能用作传统的、血小板反应性更高的血管移植材料的涂层。
