College of Nursing, All India Institute of Medical Sciences, New Delhi, India.
Leuk Lymphoma. 2013 May;54(5):1036-41. doi: 10.3109/10428194.2012.736985. Epub 2012 Nov 1.
Data on quality of life (QOL) specifically in maintenance therapy of acute lymphoblastic leukemia (ALL) are minimal. This study was done to assess various items listed in domains of QOL (physical, emotional, social and school health domains) of children with ALL during maintenance therapy, and compare the same with those of their siblings and other healthy children. Forty children on maintenance therapy of ALL, 40 siblings and 40 healthy children were assessed for QOL by child self-report using PedsQL 4.0 Generic Core in the local language. Means were computed and compared for each domain with one-way analysis of variance (ANOVA), wherein higher values reflected better QOL. Overall QOL of children with ALL in maintenance therapy (77.16 ± 10.98) was significantly poorer than that of siblings (93.56 ± 4.41) and healthy children (93.02 ± 3.76) (p < 0.001), but their abilities of self-care, household work, exercise, attentiveness, memory and homework were unaffected. There was significantly higher absenteeism due to sickness and hospital visits, and increased emotional problems (fear, anger, sleeping problems) among children with ALL. In the social health domain, children with ALL reported difficulty in maintaining friendships and competing. QOL of siblings was as good as that of healthy children in physical, social and school health domains, but they had increased emotional problems such as anger and sadness. Healthy children reported significantly higher future worries and bullying than children with ALL and siblings. This study validated that the QOL of children with ALL during maintenance therapy was significantly poorer than that of siblings and healthy children. The study identified various items in each domain of QOL that were affected in these children, and thus would assist in guiding healthcare professionals to focus on these specific items so as to improve their overall QOL.
关于生活质量（QOL）的数据，尤其是在急性淋巴细胞白血病（ALL）的维持治疗方面，数据非常有限。本研究旨在评估 ALL 维持治疗期间儿童的 QOL（身体、情感、社会和学校健康领域）各领域中的各种项目，并将其与兄弟姐妹和其他健康儿童进行比较。采用儿童自我报告的方式，使用当地语言的 PedsQL 4.0 通用核心量表，对 40 名 ALL 维持治疗的儿童、40 名兄弟姐妹和 40 名健康儿童的 QOL 进行评估。使用单因素方差分析（ANOVA）计算并比较每个领域的平均值，其中较高的值反映了更好的 QOL。与兄弟姐妹（93.56 ± 4.41）和健康儿童（93.02 ± 3.76）相比，ALL 维持治疗儿童的总体 QOL（77.16 ± 10.98）明显较差（p < 0.001），但他们的自我护理、家务劳动、运动、注意力、记忆和家庭作业能力未受影响。ALL 儿童因病缺勤和住院的情况明显更多，且情绪问题（恐惧、愤怒、睡眠问题）更多。在社会健康领域，ALL 儿童报告在维持友谊和竞争方面存在困难。在身体、社会和学校健康领域，兄弟姐妹的 QOL 与健康儿童一样好，但他们的情绪问题（愤怒和悲伤）更多。健康儿童报告的未来担忧和欺凌问题明显多于 ALL 儿童和兄弟姐妹。本研究证实 ALL 维持治疗期间儿童的 QOL 明显差于兄弟姐妹和健康儿童。该研究确定了这些儿童 QOL 各领域中的受影响项目，从而有助于指导医疗保健专业人员关注这些特定项目，以提高他们的整体 QOL。
