Batt Jeni, Linton Kerry, Bennett Paul N
Southern Health, Melbourne, Australia.
Hemodial Int. 2012 Oct;16 Suppl 1:S26-31. doi: 10.1111/j.1542-4758.2012.00747.x.
The increasing prevalence of obesity in developed countries is reflected in the chronic kidney disease, dialysis, and transplant populations. The added risk factor of obesity increases the risk of vascular events, inflammation, insulin resistance, blood pressure, dyslipidemia, and mortality risk. Nephrology center policies may exclude obese people from transplantation programs resulting in many years of dialysis. The case of a 215-kg Australian male who has successfully dialyzed at home for more than 8 years will be used to illustrate the important considerations and clinical support that these people require for successful home dialysis treatment. The aim of this paper is to report on a program that has successfully trained 23 obese (body mass index >30) people who commenced on home hemodialysis between 2001 and 2009. Body weight ranged between 94.0 and 215 kg (mean 126, SD 26.19) and body mass index ranged between 34.9 and 71 (mean 43.38, SD 9.99) at the start of home training. During the 8.5 years of follow-up, average time on home dialysis was 43.7 months. Home hemodialysis is a feasible treatment for obese people to facilitate longer and more frequent dialysis, resulting in improved hemodynamic stability and improved quality of life. For obese people with end-stage kidney disease, home hemodialysis has shown to be cost-effective and can result in greater treatment efficacy than in-center hospital dialysis.
肥胖症在发达国家的日益流行在慢性肾病、透析及移植人群中有所体现。肥胖这一额外风险因素增加了血管事件、炎症、胰岛素抵抗、血压、血脂异常及死亡风险。肾脏病中心的政策可能会将肥胖者排除在移植项目之外,导致他们需要接受多年的透析治疗。本文将以一名体重215千克的澳大利亚男性为例,他已在家成功进行透析超过8年,以此来说明这类人群成功进行家庭透析治疗所需的重要考量因素及临床支持。本文旨在报告一个成功培训了23名肥胖(体重指数>30)患者的项目,这些患者于2001年至2009年间开始进行家庭血液透析。在家训练开始时,体重范围在94.0至215千克之间(平均126千克,标准差26.19),体重指数范围在34.9至71之间(平均43.38,标准差9.99)。在8.5年的随访期间,家庭透析的平均时间为43.7个月。家庭血液透析对于肥胖者而言是一种可行的治疗方法,有助于延长透析时间并增加透析频率,从而改善血液动力学稳定性并提高生活质量。对于终末期肾病肥胖患者,家庭血液透析已证明具有成本效益,并且与医院中心透析相比可产生更高的治疗效果。