切分：菱形蛋白酶的跨膜切割促进 ERAD。
Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD.
机构信息
Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland, USA.
出版信息
Nat Struct Mol Biol. 2012 Oct;19(10):979-81. doi: 10.1038/nsmb.2398.
Abstract
Endoplasmic reticulum–associated degradation (ERAD) is a cellular protein quality-control process that disposes of proteasomal substrates from the early secretory pathway. Recent work shows that the endoplasmic reticulum–resident rhomboid protease RHBDL4 facilitates ERAD by recognizing and cleaving integral membrane substrates. The work indicates that intramembrane proteolysis may have a general role in the extraction of misfolded membrane proteins from the endoplasmic reticulum.
摘要
内质网相关降解（ERAD）是一种细胞蛋白质质量控制过程，可从早期分泌途径中处理蛋白酶体底物。最近的工作表明，内质网驻留的 rhomboid 蛋白酶 RHBDL4 通过识别和切割完整的膜底物来促进 ERAD。这项工作表明，跨膜蛋白水解可能在从内质网中提取错误折叠的膜蛋白方面具有普遍作用。
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