Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, United States of America.
Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, United States of America.
Biochim Biophys Acta Mol Cell Res. 2020 Oct;1867(10):118793. doi: 10.1016/j.bbamcr.2020.118793. Epub 2020 Jul 6.
Cells are equipped with protein quality control pathways in order to maintain a healthy proteome; a process known as protein homeostasis. Dysfunction in protein homeostasis leads to the development of many diseases that are associated with proteinopathies. Recently, the rhomboid superfamily has attracted much attention concerning their involvement in protein homeostasis. While their functional role has become much clearer in the last few years, their systemic significance in mammals remains elusive. Here we delineate the current knowledge of rhomboids in protein quality control and how these functions are integrated at the organismal level.
细胞配备了蛋白质质量控制途径，以维持健康的蛋白质组；这个过程被称为蛋白质动态平衡。蛋白质动态平衡的功能障碍导致许多与蛋白病相关的疾病的发展。最近，菱形超家族因其参与蛋白质动态平衡而受到广泛关注。虽然它们的功能作用在过去几年中变得更加清晰，但它们在哺乳动物中的系统意义仍然难以捉摸。在这里，我们描述了菱形在蛋白质质量控制中的当前知识，以及这些功能如何在机体水平上整合。
