抗磷酸丙糖异构酶自身抗体。传染性单核细胞增多症中溶血性贫血发病机制的一个可能线索。
Autoantibodies against triosephosphate isomerase. A possible clue to pathogenesis of hemolytic anemia in infectious mononucleosis.
作者信息
Ritter K, Brestrich H, Nellen B, Kratzin H, Eiffert H, Thomssen R
机构信息
Department of Medical Microbiology, University of Göttingen, Federal Republic of Germany.
出版信息
J Exp Med. 1990 Feb 1;171(2):565-70. doi: 10.1084/jem.171.2.565.
Abstract
In sera from patients with acute EBV, infection and the clinical symptoms of infectious mononucleosis antibodies of the Ig class M were found that are directed against two cellular proteins. The molecular mass of these proteins was determined to be 29 (p29) and 26 kD (p26), respectively, in SDS-PAGE. P29 was identified as part of the glycolytic enzyme triosephosphate isomerase (TPI) by comparison of the NH2-terminal amino acid sequences. A purified antibody against TPI induces a 51Cr release from human erythrocytes. Possibly, anti-TPI causes hemolysis, which is an infrequent but serious symptom of infectious mononucleosis.
摘要
在急性EBV感染患者的血清中，发现了IgM类抗体，这些抗体针对两种细胞蛋白，同时伴有传染性单核细胞增多症的临床症状。在SDS-PAGE中，这些蛋白质的分子量分别确定为29kD（p29）和26kD（p26）。通过比较NH2末端氨基酸序列，p29被鉴定为糖酵解酶磷酸丙糖异构酶（TPI）的一部分。一种纯化的抗TPI抗体可诱导人红细胞释放51Cr。抗TPI可能导致溶血，这是传染性单核细胞增多症中一种罕见但严重的症状。
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