锰超氧化物歧化酶作为急性爱泼斯坦-巴尔病毒感染中自身抗体的靶标
Manganese superoxide dismutase as a target of autoantibodies in acute Epstein-Barr virus infection.
作者信息
Ritter K, Kühl R J, Semrau F, Eiffert H, Kratzin H D, Thomssen R
机构信息
Department of Medical Microbiology, University Göttingen, Germany.
出版信息
J Exp Med. 1994 Nov 1;180(5):1995-8. doi: 10.1084/jem.180.5.1995.
Abstract
Antibodies directed against the autoantigen p26 were detected in sera from 32 patients with acute Epstein-Barr virus (EBV) infection and clinical symptoms of infectious mononucleosis. P26 has now been identified as the enzyme manganese superoxide dismutase (MnSOD) by comparison of the NH2-terminal amino acid sequence. Antibodies against MnSOD belong to the immunoglobulin class M. They are not detectable in sera of patients with other herpesvirus infections. In the 32 patients investigated, the rise and fall of the autoantibodies coincides with the clinical symptoms. In vitro, the autoantibodies were shown to inhibit the dismutation of superoxide radicals by blocking MnSOD. As presented in the discussion this effect may contribute to the pathogenesis of acute EBV infection.
摘要
在32例患有急性爱泼斯坦-巴尔病毒（EBV）感染并伴有传染性单核细胞增多症临床症状的患者血清中，检测到了针对自身抗原p26的抗体。通过比较氨基末端氨基酸序列，现已确定p26为锰超氧化物歧化酶（MnSOD）。针对MnSOD的抗体属于免疫球蛋白M类。在其他疱疹病毒感染患者的血清中未检测到此类抗体。在所研究的32例患者中，自身抗体的升高和降低与临床症状一致。在体外实验中，这些自身抗体通过阻断MnSOD来抑制超氧自由基的歧化反应。如讨论中所述，这种作用可能有助于急性EBV感染的发病机制。
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