Nam Min-Ho, Lim Jaekwan, Choi Seung-Hoon, Kim Sungchul, Soh Kwang-Sup
Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 130-701, South Korea.
J Acupunct Meridian Stud. 2012 Oct;5(5):210-7. doi: 10.1016/j.jams.2012.07.004. Epub 2012 Aug 9.
The primo vascular systems (PVS) observed in the central nervous system have been limited to the ones floating in the cerebrospinal fluid. In those experiments, it was difficult to obtain the same results because the PVS was not fixed in a given anatomical position. In the current work, we report a finding of a PVS in a well-defined location, namely, underneath the superior sagittal sinus in the sagittal fissure, so that repetition of the experiments is possible. This provides a cornerstone for PVS research because the lack of reproducible sample-taking hindered a deeper study of the PVS, such as RNA sequencing or RNA microarray. This obstacle can be overcome through the discovery in the current work. This PVS showed characteristics of the PVS observed in other organs. It showed the bundle structure of subvessels, the parallel distributions of F-actins, and the rod-shaped nuclei. Furthermore, it had a primo node in front of the confluence of sinuses above the pineal body. It had branches shooting off from the main primo vessel in the subarachnoid space toward the cerebral hemispheres. The results indicate that this PVS underneath superior sagittal sinus has proper features to function as a flowing channel.
在中枢神经系统中观察到的原始血管系统（PVS）一直局限于漂浮在脑脊液中的那些。在那些实验中，由于PVS没有固定在特定的解剖位置，很难获得相同的结果。在当前的研究中，我们报告了在一个明确位置发现的PVS，即在矢状窦裂内上矢状窦下方，这样就可以重复进行实验。这为PVS研究提供了基石，因为缺乏可重复的样本采集阻碍了对PVS的深入研究，如RNA测序或RNA微阵列。通过当前研究中的发现可以克服这一障碍。这个PVS显示出在其他器官中观察到的PVS的特征。它显示出子血管的束状结构、F-肌动蛋白的平行分布以及杆状核。此外，在松果体上方的窦汇合处前方有一个原始节点。它有分支从蛛网膜下腔的主要原始血管向大脑半球延伸。结果表明，上矢状窦下方的这个PVS具有作为流动通道的适当特征。
