Department of Electrical Engineering and Computer Science, University of California, Berkeley, CA 94720, USA.
Trends Cell Biol. 2012 Dec;22(12):617-23. doi: 10.1016/j.tcb.2012.09.002. Epub 2012 Oct 4.
The ability to synthesize biological constructs on the scale of the organisms we observe unaided is probably one of the more outlandish, yet recurring, dreams humans have had since they began to modify genes. This review brings together recent developments in synthetic biology, cell and developmental biology, computation, and technological development to provide context and direction for the engineering of rudimentary, autonomous multicellular ensembles.
能够在我们不借助工具观察到的生物体的规模上合成生物构建体，可能是人类自开始修饰基因以来最离奇但又反复出现的梦想之一。这篇综述汇集了合成生物学、细胞和发育生物学、计算和技术发展方面的最新进展，为基本自主多细胞集合体的工程提供了背景和方向。
