Department of Cardiovascular Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Asian J Androl. 2012 Nov;14(6):875-8. doi: 10.1038/aja.2012.95. Epub 2012 Oct 8.
This study aimed to determine whether plasma testosterone is associated with the severity of coronary atherosclerosis in a group of 803 men who underwent elective coronary angiography. Testosterone levels were measured in 803 male patients who were categorized into three groups according to testosterone level tertiles. All patients underwent elective coronary angiography, and the severity of coronary artery disease (CAD) was determined by the Gensini score. Moreover, patients were classified into two groups according to Gensini scores (score ≤26 and score >26) using the median values as cutoff points. The plasma testosterone levels were measured by an ELISA kit. The level of testosterone was negatively associated with the Gensini score (r=-0.188; P=0.000). A multiple linear regression analysis revealed that testosterone was an independent risk factor for the Gensini score (β=-0.110; P=0.002) after adjusting for confounding covariates. In a multivariate logistic regression model, the severity of CAD was shown to be significantly lower in the third tertile (highest) of testosterone compared to the first tertile (lowest) of testosterone (odds ratio (OR)=0.465; 95% confidence interval (CI): 0.327-0.662; P=0.000). In this study, patients with lower testosterone levels had higher Gensini scores in a group of 803 men who underwent elective coronary angiography. Additional studies are needed to clarify the direction of causality and possible underlying mechanisms.
本研究旨在确定 803 例行选择性冠状动脉造影的男性患者中，血浆睾酮水平与冠状动脉粥样硬化严重程度是否相关。根据睾酮水平三分位将 803 例男性患者分为三组，测量其睾酮水平。所有患者均行选择性冠状动脉造影，采用 Gensini 评分确定冠状动脉疾病（CAD）严重程度。此外，根据 Gensini 评分（评分≤26 和评分>26）将患者分为两组，以中位数为截断值。采用 ELISA 试剂盒测量血浆睾酮水平。睾酮水平与 Gensini 评分呈负相关（r=-0.188；P=0.000）。多元线性回归分析显示，在校正混杂因素后，睾酮是 Gensini 评分的独立危险因素（β=-0.110；P=0.002）。在多因素 logistic 回归模型中，与睾酮水平最低的第一三分位相比，第三三分位（最高）的 CAD 严重程度显著降低（比值比（OR）=0.465；95%置信区间（CI）：0.327-0.662；P=0.000）。在这项研究中，在 803 例行选择性冠状动脉造影的男性患者中，睾酮水平较低的患者 Gensini 评分较高。需要进一步的研究来阐明因果关系的方向和可能的潜在机制。
