Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Visegradska 26, Belgrade 11000, Serbia.
Postgrad Med J. 2013 Jan;89(1047):8-13. doi: 10.1136/postgradmedj-2012-131005. Epub 2012 Oct 5.
To evaluate health-related quality of life (HRQoL) in patients with symptomatic carotid disease (amaurosis fugax, transient ischaemic attack, stroke); to compare it with that of the general population; to explore whether HRQoL depends on the severity of the disease and to investigate the possible association between some demographic and clinical characteristics of patients and HRQoL.
This cross-sectional study involved 175 patients with symptomatic carotid atherosclerotic disease who were referred for endarterectomy between January 2011 and December 2011. HRQoL was measured using Medical Outcome Survey Short Form 36 (SF-36).
In comparison to both referent populations, patients with carotid disease had significantly lower mean SF-36 scores for role-physical (41.6 vs. 61.5 and 67.8), social functioning (65.4 vs. 73.8 and 80.0), role-emotional (48.2 vs. 68.6 and 80.5) and mental health (51.5 vs. 61.9 and 66.0). The SF-36 scores were significantly lower in female patients with carotid disease than in men (for role-physical 32.3 vs. 46.5; for bodily pain 57.0 vs. 73.0; for general health 55.6 vs. 61.5; for vitality 55.4 vs. 60.1; for social functioning 57.1 vs. 69.8 and for role-emotional 37.2 vs. 54.1). Significantly lower SF-36 scores were also found in patient with comorbidity (for physical functioning 68.1 vs. 77.7; for role-physical 35.1 vs. 52.3; for bodily pain 62.6 vs. 75.4; for general health 56.8 vs. 63.8; for social functioning 61.9 vs. 71.0, for role-emotional 41.6 vs. 59.1and for mental health 52.5 vs 49.8). In a multivariable analysis, education, occupation, body mass index, metabolic syndrome and severity of the disease had a weak influence on patients' HRQoL, while age, marital status, smoking, alcohol consumption, physical activity and the degree of carotid stenosis had no effect on patients' HRQoL. The SF-36 scores did not substantially change after adjustment for confounding variables.
Patients with symptomatic carotid disease had poorer HRQoL, especially its mental components, than the general population. The severity of the disease was significantly associated only with the SF-36 role-physical subscale. HRQoL in patients with symptomatic carotid disease was poorer in women than in men, and was not affected by age and other demographic and clinical characteristics of patients.
评估有症状颈动脉疾病（一过性黑矇、短暂性脑缺血发作、卒中等）患者的健康相关生活质量（HRQoL）；将其与普通人群进行比较；探讨 HRQoL 是否取决于疾病的严重程度，并研究患者的一些人口统计学和临床特征与 HRQoL 之间的可能关联。
这是一项 2011 年 1 月至 12 月期间因颈动脉内膜切除术而被转介的 175 例有症状颈动脉粥样硬化性疾病患者的横断面研究。使用医疗结局研究短式 36 项健康调查量表（SF-36）来衡量 HRQoL。
与两个参照人群相比，颈动脉疾病患者的 SF-36 量表角色躯体（41.6 分比 61.5 分和 67.8 分）、社会功能（65.4 分比 73.8 分和 80.0 分）、角色情绪（48.2 分比 68.6 分和 80.5 分）和心理健康（51.5 分比 61.9 分和 66.0 分）的平均得分明显较低。颈动脉疾病女性患者的 SF-36 量表评分明显低于男性（角色躯体 32.3 分比 46.5 分；躯体疼痛 57.0 分比 73.0 分；一般健康 55.6 分比 61.5 分；活力 55.4 分比 60.1 分；社会功能 57.1 分比 69.8 分和角色情绪 37.2 分比 54.1 分）。合并症患者的 SF-36 量表评分也明显较低（躯体功能 68.1 分比 77.7 分；角色躯体 35.1 分比 52.3 分；躯体疼痛 62.6 分比 75.4 分；一般健康 56.8 分比 63.8 分；社会功能 61.9 分比 71.0 分，角色情绪 41.6 分比 59.1 分和心理健康 52.5 分比 49.8 分）。在多变量分析中，教育程度、职业、体重指数、代谢综合征和疾病严重程度对患者的 HRQoL 有微弱影响，而年龄、婚姻状况、吸烟、饮酒、体力活动和颈动脉狭窄程度对患者的 HRQoL 没有影响。在调整混杂因素后，SF-36 量表评分没有明显变化。
有症状颈动脉疾病患者的 HRQoL 较差，尤其是其精神成分，明显低于普通人群。疾病的严重程度仅与 SF-36 角色躯体分量表显著相关。有症状颈动脉疾病患者中，女性患者的 HRQoL 比男性差，且不受年龄和患者其他人口统计学和临床特征的影响。
