不同程度碱性反流对胃残端和食管的影响：一项在猪身上的实验研究

Effect of different fractions of alkaline reflux on the gastric stump and the esophagus: an experimental research on pigs.

作者信息

Clemente G, Manni R, Vecchio F M, Rizzo S, Furgiuele S, Perrotti P, Crucitti F

机构信息

Department of Surgery, Agostino Gemelli Medical School, Catholic University of Sacred Heart, Rome, Italy.

出版信息

J Surg Res. 1990 Feb;48(2):121-6. doi: 10.1016/0022-4804(90)90203-e.

DOI:10.1016/0022-4804(90)90203-e

PMID:2304339

Abstract

An experimental study was conducted to evaluate the effect of different fractions (bile and pancreaticoduodenal secretions) on the gastric stump and esophageal mucosa. Twenty pigs underwent partial gastrectomy (two-third distal) and cardiomyotomy in order to induce free gastroesophageal reflux. Then, reconstruction of the alimentary tract was performed to assess the effects of different types of alkaline reflux. A combined (biliary and pancreaticoduodenal) reflux, an isolated biliary reflux, and an isolated pancreaticoduodenal reflux were induced, respectively, in three different groups of five pigs each. In a control group a Roux-en-Y gastrojejunostomy was performed. Nine months later, the animals were sacrificed, the esophagus and the gastric stump were removed for histologic examination. The results show that the most severe histopathological lesions are determined by combined alkaline reflux; on the other hand, separated fractions can induce only mild changes on the gastric stump and esophageal mucosa.

摘要

进行了一项实验研究，以评估不同成分（胆汁和胰十二指肠分泌物）对胃残端和食管黏膜的影响。20头猪接受了部分胃切除术（远端三分之二）和贲门肌切开术，以诱发自由性胃食管反流。然后，进行消化道重建，以评估不同类型碱性反流的影响。分别在三组不同的猪中诱发联合（胆汁和胰十二指肠）反流、单独的胆汁反流和单独的胰十二指肠反流，每组5头猪。在对照组中进行了Roux-en-Y胃空肠吻合术。9个月后，处死动物，取出食管和胃残端进行组织学检查。结果表明，最严重的组织病理学损伤是由联合碱性反流决定的；另一方面，单独的成分只会在胃残端和食管黏膜上引起轻微变化。