原发性骨髓增生异常综合征的骨髓培养与预后

Bone marrow cultures and prognosis in primary myelodysplastic syndromes.

作者信息

Korthout M, De Bock R, van Bockstaele D, Peetermans M

机构信息

Laboratory of Experimental Haematology, University of Antwerp, Wilrijk, Belgium.

出版信息

Leuk Res. 1990;14(1):85-9. doi: 10.1016/0145-2126(90)90150-8.

DOI:10.1016/0145-2126(90)90150-8

PMID:2304356

Abstract

Bone marrow cultures and survival time were studied in 39 patients with primary myelodysplastic syndromes. We divided the patients into two groups according to the CFU-GM numbers on day 10: type I with low colony (CFU-GM less than 30) and type II with normal to high colony formation (CFU-GM greater than or equal to 30). The median survival time was shorter for patients with an in vitro growth type II (5 months) than it was for patients with an in vitro growth type I (greater than 36 months). No relations was found between growth types and FAB-type, Bournemouth score or initial karyotype. The initial bone marrow blast percentage correlated well with the in vitro growth number.

摘要

对39例原发性骨髓增生异常综合征患者进行了骨髓培养和生存时间研究。我们根据第10天的CFU - GM数量将患者分为两组：I型为低集落组（CFU - GM少于30），II型为集落形成正常至高集落组（CFU - GM大于或等于30）。体外生长为II型的患者中位生存时间（5个月）比体外生长为I型的患者（大于36个月）短。未发现生长类型与FAB分型、伯恩茅斯评分或初始核型之间存在关联。初始骨髓原始细胞百分比与体外生长数量密切相关。