Tennant G B, Jacobs A, Bailey-Wood R
Exp Hematol. 1986 Dec;14(11):1063-8.
Peripheral blood (PB) granulocyte-macrophage progenitor (CFU-GM) growth was measured in 47 normal subjects and, together with bone marrow CFU-GM and blast cell numbers, in 45 newly diagnosed patients with myelodysplastic syndromes (MDS). Both PB colony and cluster numbers were significantly reduced in MDS patients. In patients with greater than 5% marrow blasts there was a negative correlation between blast cell numbers and PB colony growth. Bone marrow and PB colony growth were also well correlated in this group. Poor growth of PB CFU-GM appears to be more closely related to prognosis than does bone marrow progenitor growth.
对47名正常受试者的外周血（PB）粒细胞-巨噬细胞祖细胞（CFU-GM）生长情况进行了检测，并对45例新诊断的骨髓增生异常综合征（MDS）患者同时检测了骨髓CFU-GM和原始细胞数量。MDS患者的外周血集落和集簇数量均显著减少。骨髓原始细胞大于5%的患者，原始细胞数量与外周血集落生长呈负相关。该组患者的骨髓和外周血集落生长也具有良好的相关性。与骨髓祖细胞生长相比，外周血CFU-GM生长不良似乎与预后关系更为密切。
