Rose H, Busse E, Riessbeck K H
Onkologie. 1979 Aug;2(4):176-80. doi: 10.1159/000214605.
Changes in the concentration of cyclic AMP as well as cyclic GMP were measured in different murine tumors and in human tumors of varying malignancy. The quotient of cAMP and cGMP seems to be an important parameter for the molecular-biological derangement. Because of the recently much discussed importance of cAMP and cGMP in the immune defence the changes in the concentration of both nucleotides were measured in the T-lymphocytes of tumor patients. Significant changes occurred in patients with malignant melanoma. Investigations of the stimulatibility of the cAMP and cGMP levels revealed a diminished activatibility of the cAMP level and a higher stimulatibility of the cGMP level in the T-lymphocytes of patients with malignant melanoma as compared with those of the controls. On the basis of the working hypothesis that there is a causal relationship between the deranged dualism of cAMP and cGMP in the T-lymphocytes and the failure of the immunological tumor cell defence, an increase in the cAMP level is offered as a possible therapy. Therapeutic results in tumor-bearing mice and first results in melanoma patients are discussed.
在不同的鼠类肿瘤以及不同恶性程度的人类肿瘤中，对环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）的浓度变化进行了测量。cAMP与cGMP的比值似乎是分子生物学紊乱的一个重要参数。由于最近人们对cAMP和cGMP在免疫防御中的重要性进行了大量讨论，因此对肿瘤患者的T淋巴细胞中这两种核苷酸的浓度变化进行了测量。恶性黑色素瘤患者出现了显著变化。对cAMP和cGMP水平的刺激反应性研究表明，与对照组相比，恶性黑色素瘤患者T淋巴细胞中cAMP水平的激活能力降低，而cGMP水平的刺激反应性更高。基于T淋巴细胞中cAMP和cGMP的二元性紊乱与免疫肿瘤细胞防御功能失败之间存在因果关系这一工作假设，提出提高cAMP水平作为一种可能的治疗方法。讨论了荷瘤小鼠的治疗结果以及黑色素瘤患者的初步结果。
