Veksler I G, Antonenko S G, Okolot E N, Chubinskaia S G
Eksp Onkol. 1984;6(3):52-5.
It is shown that zymosan, prodigiosan, tiloron and levamisol have a different effect on the level of cyclic nucleotides and the cAMP/cGMP correlation in the lungs, thymus and spleen of mice during metastatic spreading of the Lewis carcinoma. A more pronounced antimetastatic effect after administration of immunomodulators is accompanied by a more considerable increase in the cAMP/cAMP coefficient in immunocompetent organs. There exists a close negative correlation between the increase in the cAMP/cGMP coefficient in the thymus and spleen, on the one hand, and inhibition of the metastatic spreading in the lungs under the effect of levamisol and zymosan, on the other.
