Busse E, Rose H, Riessbeck K H
J Cancer Res Clin Oncol. 1979 Jun 8;94(2):121-30. doi: 10.1007/BF00422492.
During chemical carcinogenesis by 9, 10-dimethyl 1,2-benzanthracene the cyclic AMP and GMP content was measured in the skin of mice. The tissue of the developing skin tumor is characterized by an elevated cyclic GMP- and a lowered cyclic AMP level. Consequently the quotient of cyclic AMP and GMP is greatly lowered and is discussed as a crucial factor of cell derangement. Complete regression of the tumor is to be achieved by increasing the cyclic AMP levels by means of cyclic DBAMP and L-Dopa in 20% of the experimental animals. Additional stimulation by BCG of the unspecific immune defence has a favourable effect on tumor regression (about 50%). In a different type of tumor (solid Ehrlich carcinoma) it was possible after pretreatment of the mice with L-Dopa, cyclic DBAMP and BCG and after treatment following tumor injection to prevent tumor development in 67% of the animals.
在用9,10 - 二甲基 - 1,2 - 苯并蒽进行化学致癌过程中，对小鼠皮肤中的环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）含量进行了测定。正在形成的皮肤肿瘤组织的特征是环磷酸鸟苷水平升高而环磷酸腺苷水平降低。因此，环磷酸腺苷与环磷酸鸟苷的比值大幅降低，并被认为是细胞紊乱的关键因素。通过环磷腺苷双丁酯（cyclic DBAMP）和左旋多巴（L - Dopa）提高环磷酸腺苷水平，在20%的实验动物中可实现肿瘤的完全消退。卡介苗（BCG）对非特异性免疫防御的额外刺激对肿瘤消退有有利影响（约50%）。在另一种类型的肿瘤（实体艾氏癌）中，在用左旋多巴、环磷腺苷双丁酯和卡介苗对小鼠进行预处理后，以及在肿瘤接种后进行治疗，67%的动物可预防肿瘤发展。
