Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Tromsø, Norway.
Comp Immunol Microbiol Infect Dis. 2013 May;36(3):241-8. doi: 10.1016/j.cimid.2012.09.001. Epub 2012 Oct 6.
Although a "One Health" approach has been successfully implemented for emerging infectious zoonotic diseases with pandemic potential, we still lack a conceptual framework to address enzootic diseases like brucellosis. The vast majority of published brucellosis studies in the developing world rely solely on serology. An important shortcoming of brucellosis serology is the impossibility to infer which (smooth) Brucella spp. induced antibodies in the host. In this respect, mixed farming and especially raising small ruminants along with cattle, a common practice in the developing world, is reported to be a risk factor and a central question that has to be answered is whether cattle are infected with B. melitensis or with B. abortus or with both Brucella species. Therefore the isolation, identification and molecular characterization of Brucella spp. in human and the different livestock species needs to be undertaken to define a sound conceptual framework, identify the source of infection and plan appropriate control measures.
虽然“同一健康”方法已成功应用于具有大流行潜力的新发人畜共患传染病，但我们仍然缺乏一个概念框架来解决布鲁氏菌病等地方病。发展中国家发表的绝大多数布鲁氏菌病研究仅依赖血清学。布鲁氏菌病血清学的一个重要缺点是不可能推断出哪种（光滑）布鲁氏菌属在宿主中诱导了抗体。在这方面，混合养殖，特别是在发展中国家常见的与牛一起饲养小反刍动物，被报道为一个风险因素，一个必须回答的核心问题是牛是否感染了牛种布鲁氏菌或流产布鲁氏菌或两种布鲁氏菌。因此，需要对人类和不同牲畜物种中的布鲁氏菌属进行分离、鉴定和分子特征分析，以制定合理的概念框架，确定感染源，并计划采取适当的控制措施。
