Federal Institute for Risk Assessment, Hygiene and Microbiology, Diedersdorfer Weg 1, D-12277 Berlin, Germany.
Expert Rev Anti Infect Ther. 2011 Jul;9(7):833-45. doi: 10.1586/eri.11.55.
Brucellosis is a worldwide zoonosis with a huge economic impact on animal husbandry and public health. The diagnosis of human brucellosis can be protracted because the disease primarily presents as fever of unknown origin with unspecific clinical signs and symptoms. The isolation rate of the fastidious etiologic agent from blood cultures is low, and therefore laboratory diagnosis is mainly based on serologic and molecular testing. However, seronegative brucellosis patients have been described, and antibody titers of diagnostic significance are difficult to define. Whether the molecular detection of Brucella DNA in clinical samples should be followed by long-term antibiotic treatment or not is also a matter of debate. The aim of this article is to review and discuss the implications of laboratory test results in the diagnosis of human brucellosis on disease therapy.
布鲁氏菌病是一种全球性的动物传染病，对畜牧业和公共卫生造成了巨大的经济影响。人类布鲁氏菌病的诊断可能会很漫长，因为该病主要表现为原因不明的发热，伴有非特异性的临床体征和症状。从血液培养中分离出这种难以培养的病原体的分离率较低，因此实验室诊断主要基于血清学和分子检测。然而，已经描述了血清阴性布鲁氏菌病患者，并且难以确定具有诊断意义的抗体滴度。在临床样本中检测到布鲁氏菌 DNA 后是否应进行长期抗生素治疗，这也是一个有争议的问题。本文的目的是回顾和讨论实验室检测结果对人类布鲁氏菌病治疗的影响。
