Saldanha Karine Dantas Diógenes, Machado Filho Carlos D'Apparecida Santos, Paschoal Francisco Macedo
Faculdade de Medicina do ABC, Santo André, SP, Brazil.
An Bras Dermatol. 2012 Sep-Oct;87(5):685-90. doi: 10.1590/s0365-05962012000500002.
Vitiligo is a prevalent skin pigmentation disorder worldwide. The treatments available still offer limited results to some patients. For patients with clinically stable vitiligo, melanocyte transplantation is an appropriate treatment option, and the technique of autologous punch grafting shows good repigmentation.
To evaluate the effect of topical mometasone on the halos of repigmentation after autologous punch grafting in patients with clinically stable vitiligo.
Between 2009 and 2010, 11 patients with clinically stable vitiligo (7 generalized, 2 focal and 2 segmental) underwent autologous punch grafting in the achromic patches. According to the clinical type of vitiligo, patients were instructed to use the corticosteroid ointment during 6 months, only on a few grafted lesions. In the first month, the mometasone ointment was used twice a day and after that just once. They were reassessed 1, 3 and 6 months after the procedure. Grafted halos were photographed and recorded using the software fotofinder. After 6 months, all the treated and untreated areas of the repigmentation halos were measured and analyzed comparatively.
The median area of the repigmentation halos after 6 months of treatment with mometasone was larger (25,96 mm(2)) than the one of the untreated halos (13,86 mm(2)), showing a statistically significant difference (p = 0,026).
In this study, the use of mometasone ointment increased the area of the repigmentation halos after punch grafting. However, this should be further investigated in larger samples in order to validate this positive action in the treatment of stable vitiligo.
白癜风是一种在全球范围内普遍存在的皮肤色素沉着紊乱疾病。现有的治疗方法对一些患者的效果仍然有限。对于临床症状稳定的白癜风患者，黑素细胞移植是一种合适的治疗选择，而自体钻孔移植技术显示出良好的色素再生效果。
评估外用莫米松对临床症状稳定的白癜风患者自体钻孔移植后色素再生晕轮的影响。
2009年至2010年期间，11例临床症状稳定的白癜风患者（7例泛发型、2例局限型和2例节段型）在色素脱失斑处接受了自体钻孔移植。根据白癜风的临床类型，指导患者在6个月内仅在少数移植部位使用糖皮质激素软膏。第一个月，每天使用两次莫米松软膏，之后每天使用一次。在手术后1、3和6个月对患者进行重新评估。使用fotofinder软件对移植的晕轮进行拍照和记录。6个月后，对色素再生晕轮的所有治疗和未治疗区域进行测量并比较分析。
使用莫米松治疗6个月后，色素再生晕轮的中位面积（25.96平方毫米）大于未治疗晕轮的面积（13.86平方毫米），差异具有统计学意义（p = 0.026）。
在本研究中，使用莫米松软膏增加了钻孔移植后色素再生晕轮的面积。然而，这一结果应在更大样本中进一步研究，以验证其在稳定型白癜风治疗中的积极作用。
