自体微小钻孔移植治疗稳定型和顽固性白癜风：1000例患者的前瞻性研究
Treatment of stable and recalcitrant vitiligo by autologous miniature punch grafting: a prospective study of 1,000 patients.
作者信息
Malakar S, Dhar S
机构信息
Duncan Gleneagles Clinic and Research Centre, Calcutta, India.
出版信息
Dermatology. 1999;198(2):133-9. doi: 10.1159/000018089.
BACKGROUND
Stable and refractory vitiligo may be unresponsive to medical therapy. Melanocyte transplantation by punch grafting (PG) can restore the normal pigmentation.
OBJECTIVE
To evaluate the efficacy of PG on repigmentation of vitiligo patches.
METHODS
Autologous miniature PG was undertaken in 1,000 patients with stable and recalcitrant vitiligo. Test grafting (TG) was done in all the patients. Those who showed negative TG results were excluded from the study.
RESULTS
Of the 1,000 patients, 880 (88%) showed positive TG results. In 656 (74.55%) patients, 90-100% repigmentation was achieved. In 93 (10.57%) patients, there was no spread of pigment, while in 21 (2.39%) patients depigmentation of the graft(s) was notices. Of various complications, polka dot appearance (43.98%) and colour mismatch (34.32%) were most frequent.
CONCLUSION
Partial to near-total repigmentation of a vitiligo patch can be achieved by PG.
背景
稳定型和难治型白癜风可能对药物治疗无反应。钻孔移植（PG）黑素细胞移植可恢复正常色素沉着。
目的
评估PG对白癜风斑块色素再生的疗效。
方法
对1000例稳定型和顽固性白癜风患者进行自体微型PG。所有患者均进行了试验性移植（TG）。那些TG结果为阴性的患者被排除在研究之外。
结果
1000例患者中，880例（88%）TG结果为阳性。656例（74.55%）患者实现了90%-100%的色素再生。93例（10.57%）患者色素未扩散，21例（2.39%）患者移植部位出现色素脱失。在各种并发症中，最常见的是点状外观（43.98%）和颜色不匹配（34.32%）。
结论
PG可使白癜风斑块部分至几乎完全色素再生。
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