Fucic A, Horvat D, Dimitrovic B
Institute for Medical Research and Medical Health, Zagreb, Yugoslavia.
Mutat Res. 1990 Feb;243(2):95-9. doi: 10.1016/0165-7992(90)90029-j.
A group of 67 workers occupationally exposed to VCM was examined for the presence and distribution of breaks along the chromosomal length. Breaks induced by VCM are not randomly distributed as had been expected in a normal population. According to our results there exist highly sensitive and highly resistant locations along the chromosomes to the actions of VCM. The link between the highly sensitive segments of chromosomes, fragile sites and the activation of oncogenes is discussed.
对一组67名职业性接触氯乙烯的工人进行了检查，以确定染色体长度上断裂的存在和分布情况。氯乙烯诱导的断裂并非如正常人群中所预期的那样随机分布。根据我们的结果，染色体上存在对氯乙烯作用高度敏感和高度抗性的位点。本文讨论了染色体高敏区段、脆性位点与癌基因激活之间的联系。
