Purchase I F, Richardson C R, Anderson D, Paddle G M, Adams W G
Mutat Res. 1978 Jul;57(3):325-34. doi: 10.1016/0027-5107(78)90217-8.
Chromosomal morphology from cultured peripheral lymphocytes was studied in 81 men; 57 of the men were employed on plants manufacturing vinyl chloride or polyvinylchloride, 19 were on-site controls and 5 were off-site controls. There was a significant increase in chromosomal abnormalities in the exposed workers when compared with the controls. The greatest statistically significant increase in total B and total C cells occurred in autoclave operators, with smaller increases in other job categories. The increase in chromosomal aberrations was correlated with the length of exposure and with a history during the year prior to sampling (1973--1974) of exposure to excursion levels of vinyl chloride. Information on smoking habits was obtained 18 months after blood sampling and a positive correlation between these and total C cell abnormalities was found. There was no positive correlation with various other parameters (bilirubin, platelets, gamma-glutamyltranspeptidase, alkaline phosphatase, alanine transaminase and aspartate transaminase). It was not possible to estimate which of the three parameters (smoking history, length of employment or exposure to excursion levels) was the most important.
对81名男性的培养外周淋巴细胞的染色体形态进行了研究；其中57名男性受雇于生产氯乙烯或聚氯乙烯的工厂，19名是现场对照人员，5名是场外对照人员。与对照组相比，接触组工人的染色体异常有显著增加。在高压灭菌器操作人员中，总B细胞和总C细胞的统计学显著增加最为明显，其他工作类别中的增加幅度较小。染色体畸变的增加与接触时间以及采样前一年（1973 - 1974年）接触氯乙烯异常水平的历史有关。在采血18个月后获得了吸烟习惯信息，发现吸烟习惯与总C细胞异常之间存在正相关。与其他各种参数（胆红素、血小板、γ-谷氨酰转肽酶、碱性磷酸酶、丙氨酸转氨酶和天冬氨酸转氨酶）没有正相关。无法估计这三个参数（吸烟史、工作年限或接触异常水平）中哪一个最重要。
