雄性大鼠反复接触氯乙烯或偏二氯乙烯后的显性致死研究。

A dominant lethal study in male rats after repeated exposures to vinyl chloride or vinylidene chloride.

作者信息

Short R D, Minor J L, Winston J M, Lee C C

出版信息

J Toxicol Environ Health. 1977 Dec;3(5-6):965-8. doi: 10.1080/15287397709529630.

Abstract

Male CD rats were exposed 6 hr/day for 5 days/wk to 0, 50, 250, or 1,000 ppm of vinyl chloride or 55 ppm of vinylidene chloride. Starting on week 11 of exposure, these males were mated with untreated females. There was no evidence of either preimplantation loss or postimplanation loss in pregnant females that resulted from these matings. Consequently, it was concluded that these exposures did not produce germinal mutation, as manifested by a dominant lethal effect, in male rats.

摘要

雄性CD大鼠每周5天，每天暴露于0、50、250或1000 ppm的氯乙烯或55 ppm的偏二氯乙烯中6小时。从暴露的第11周开始，将这些雄性大鼠与未处理的雌性大鼠交配。这些交配所产生的怀孕雌性大鼠中，没有着床前损失或着床后损失的证据。因此，得出结论：这些暴露未在雄性大鼠中产生显性致死效应所表现的生殖细胞突变。