Bean A J, During M J, Roth R H
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510.
Neurosci Lett. 1990 Jan 1;108(1-2):143-8. doi: 10.1016/0304-3940(90)90721-k.
The in vivo release of dopamine and neurotensin from the rat medial prefrontal cortex was studied using perfusion microdialysis coupled with sensitive radioimmunoassay and HPLC techniques. Following stimulation of dopamine autoreceptors with either apomorphine (30 micrograms/kg, s.c.) or EMD-23448 (10 microM in the perfusion buffer) a decrease in dopamine and an increase in neurotensin release was observed. The release of both substances was measured in the same dialysis sample. These data suggest that activation of dopamine autoreceptors in the prefrontal cortex produces opposing effects on the release of dopamine and neurotensin.
利用灌注微透析结合灵敏的放射免疫测定法和高效液相色谱技术，研究了大鼠内侧前额叶皮质中多巴胺和神经降压素的体内释放情况。用阿扑吗啡（30微克/千克，皮下注射）或EMD - 23448（灌注缓冲液中10微摩尔）刺激多巴胺自身受体后，观察到多巴胺释放减少，神经降压素释放增加。两种物质的释放在同一样透析样品中进行测定。这些数据表明，前额叶皮质中多巴胺自身受体的激活对多巴胺和神经降压素的释放产生相反的影响。
