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前额叶皮质中刺激诱导的共存递质释放：多巴胺和神经降压素释放的体内微透析研究

Stimulation-induced release of coexistent transmitters in the prefrontal cortex: an in vivo microdialysis study of dopamine and neurotensin release.

作者信息

Bean A J, During M J, Roth R H

机构信息

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510.

出版信息

J Neurochem. 1989 Aug;53(2):655-7. doi: 10.1111/j.1471-4159.1989.tb07384.x.

DOI:10.1111/j.1471-4159.1989.tb07384.x
PMID:2568407
Abstract

Extracellular fluid levels of dopamine and neurotensin in the rat prefrontal cortex were measured using in vivo microdialysis. Electrical stimulation of the median forebrain bundle resulted in increased release of both dopamine and neurotensin from the prefrontal cortex. Thus, stimulation of neurons in which dopamine and neurotensin are colocalized can evoke the in vivo release of both substances.

摘要

采用体内微透析法测定大鼠前额叶皮质细胞外液中多巴胺和神经降压素的水平。电刺激中脑前脑束可导致前额叶皮质中多巴胺和神经降压素的释放增加。因此，刺激多巴胺和神经降压素共定位的神经元可引起这两种物质在体内的释放。

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