辣椒素诱导的降钙素基因相关肽在血管灌流大鼠胃中的释放
Release of calcitonin gene-related peptide induced by capsaicin in the vascularly perfused rat stomach.
作者信息
Holzer P, Peskar B M, Peskar B A, Amann R
机构信息
University of Bochum Department of Experimental Clinical Medicine, Bochum, F.R.G.
出版信息
Neurosci Lett. 1990 Jan 1;108(1-2):195-200. doi: 10.1016/0304-3940(90)90730-w.
It has been suggested that capsaicin-induced gastric mucosal protection results from the local release of vasodilator peptides such as calcitonin gene-related peptide (CGRP) from afferent nerve endings within the stomach, since CGRP is able to reduce gastric lesion formation. This concept is supported by the present finding that capsaicin (10(-5) M), administered to the vascularly perfused stomach of the rat, produces a more than 30-fold rise of the CGRP content of the venous effluent. High-pressure liquid chromatography revealed only one peak of immunoreactivity coeluting with synthetic CGRP.
有人提出，辣椒素诱导的胃黏膜保护作用是由于胃内传入神经末梢局部释放血管舒张肽，如降钙素基因相关肽（CGRP），因为CGRP能够减少胃损伤的形成。这一观点得到了目前研究结果的支持，即给大鼠血管灌注胃施用辣椒素（10^(-5) M）后，静脉流出液中CGRP含量会增加30倍以上。高压液相色谱显示，只有一个免疫反应峰与合成CGRP共洗脱。
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