辣椒素敏感神经在表皮生长因子对胃黏膜损伤和血流影响中的作用。
Role of capsaicin sensitive nerves in epidermal growth factor effects on gastric mucosal injury and blood flow.
作者信息
Kang J Y, Teng C H, Chen F C, Wee A
机构信息
Department of Medicine, National University of Singapore.
出版信息
Gut. 1998 Mar;42(3):344-50. doi: 10.1136/gut.42.3.344.
BACKGROUND
Epidermal growth factor (EGF) and capsaicin protect against experimental gastric mucosal injury. Capsaicin exerts its gastroprotective effect by stimulating afferent neurones leading to release of calcitonin gene related peptide (CGRP) which causes gastric hyperaemia. EGF also causes gastric hyperaemia but whether it acts via capsaicin sensitive neurones is unknown.
AIMS
To assess the influence of: (1) capsaicin desensitisation on EGF effects on gastric mucosal injury and gastric mucosal blood flow: and (2) close arterial infusion of hCGRP8-379, a CGRP antagonist, on EGF effects on gastric mucosal blood flow.
METHODS
The absolute ethanol induced gastric mucosal injury model in the rat was used. Gastric mucosal damage was assessed by planimetry and light microscopy. Gastric mucosal blood flow was measured by laser Doppler flowmetry in a gastric chamber preparation.
RESULTS
Capsaicin desensitisation abolished the gastroprotective and gastric hyperaemic effects of EGF. Close arterial infusion of hCGRP8-37 antagonised the hyperaemic effect of both capsaicin and EGF.
CONCLUSION
Results show that EGF may exert its gastroprotective and gastric hyperaemic effects via capsaicin sensitive afferent neurones.
背景
表皮生长因子（EGF）和辣椒素可预防实验性胃黏膜损伤。辣椒素通过刺激传入神经元释放降钙素基因相关肽（CGRP）发挥胃保护作用，CGRP可引起胃充血。EGF也可引起胃充血，但它是否通过对辣椒素敏感的神经元起作用尚不清楚。
目的
评估：（1）辣椒素脱敏对EGF对胃黏膜损伤和胃黏膜血流的影响；（2）动脉内近距离输注CGRP拮抗剂hCGRP8 - 37对EGF对胃黏膜血流的影响。
方法
采用大鼠无水乙醇诱导的胃黏膜损伤模型。通过面积测量法和光学显微镜评估胃黏膜损伤。在胃腔制备中用激光多普勒血流仪测量胃黏膜血流。
结果
辣椒素脱敏消除了EGF的胃保护和胃充血作用。动脉内近距离输注hCGRP8 - 37拮抗辣椒素和EGF的充血作用。
结论
结果表明，EGF可能通过对辣椒素敏感的传入神经元发挥其胃保护和胃充血作用。
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