University of North Carolina, School of Medicine, Department of Orthopaedics, Campus Box #7055, Bioinformatics Building, Chapel Hill, NC 27599-7055, USA.
J Orthop Surg Res. 2012 Oct 9;7:34. doi: 10.1186/1749-799X-7-34.
A recent study from our laboratory has demonstrated improved range of motion in the toes of broiler chickens afflicted with pyogenic flexor tenosynovitis when treated with local antibiotic and corticosteroid injections, without surgical drainage. However, the use of corticosteroids as an adjunct treatment raised peer concern, as steroids are thought to have deleterious effects on tendon strength. The purpose of this study was to compare the tensile strength of the aforementioned steroid treated tendons, to a group of tendons administered with the current standard treatment: systemic antibiotics, surgical drainage and no corticosteroids.
Twenty-three tendons' structural and material properties were investigated (fifteen receiving the standard treatment, eight receiving the steroid treatment). The measurements from each group were interpreted via Student's unpaired t-test and a post-hoc power analysis.
The steroid treated tendons did demonstrate a trend toward decreased mechanical properties when compared with the standard treatment group, but the results were not statistically significant.
Treatment of septic tenosynovitis with local corticosteroid and local antibiotic injections resulted in better digital motion, without a significant loss of tendon strength, over a twenty-eight day recovery period.
我们实验室最近的一项研究表明,患有化脓性屈肌腱腱鞘炎的肉鸡在接受局部抗生素和皮质类固醇注射治疗(无需手术引流)时,其脚趾的活动范围有所改善。然而,皮质类固醇作为辅助治疗的使用引起了同行的关注,因为皮质类固醇被认为对肌腱强度有有害影响。本研究的目的是比较上述皮质类固醇治疗的肌腱与接受当前标准治疗(全身抗生素、手术引流和无皮质类固醇)的肌腱的拉伸强度。
研究了 23 根肌腱的结构和材料特性(15 根接受标准治疗,8 根接受皮质类固醇治疗)。通过学生的独立样本 t 检验和事后功效分析对每组的测量值进行解释。
与标准治疗组相比,皮质类固醇治疗的肌腱的机械性能确实有下降的趋势,但结果没有统计学意义。
在 28 天的恢复期内,局部皮质类固醇和局部抗生素注射治疗脓毒性腱鞘炎可改善手指运动,而不会显著降低肌腱强度。