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基于甲川花菁的新型远可见和近红外 pH 探针，用于活细胞内 pH 成像。

Novel far-visible and near-infrared pH probes based on styrylcyanine for imaging intracellular pH in live cells.

机构信息

College of Chemistry and Chemical Engineering, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, PR China.

出版信息

Chem Commun (Camb). 2012 Nov 25;48(91):11202-4. doi: 10.1039/c2cc35363f.

DOI:10.1039/c2cc35363f
PMID:23047294
Abstract

Two novel vis-NIR pH probes based on styrylcyanine with acidic pH response are easily synthesized, which display large Stokes shift and high sensitivity. The significant colocalizations of two probes with LysoTracker Green DND-26 are achieved in C6 cells, suggesting potential application for imaging acidic organelles in live cells.

摘要

两种基于具有酸性 pH 响应的苯乙烯基菁的新型可见近红外 pH 探针易于合成，具有较大的斯托克斯位移和高灵敏度。两种探针与 LysoTracker Green DND-26 在 C6 细胞中的显著共定位，表明其在活细胞中成像酸性细胞器的潜在应用。

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