Department of Internal Medicine, Division of Medicine, Akershus University Hospital, Lorenskog, Norway.
Heart. 2013 Jan;99(1):30-4. doi: 10.1136/heartjnl-2012-303009. Epub 2012 Oct 9.
Obstructive sleep apnoea (OSA) and obesity are both associated with endothelial dysfunction, which precedes the development of atherosclerosis. As obesity is highly prevalent in OSA, we wanted to test the hypothesis that OSA is associated with endothelial dysfunction independently of obesity.
Cross-sectional, population-based study.
Norwegian university hospital.
Seventy-one subjects (median age 44 years, 35% female) were recruited from a population-based study in Norway. Participants were categorised as obese (body mass index (BMI) ≥30 kg/m(2)), non-obese (BMI<30 kg/m(2)) with OSA (apnoea-hypopnoea index (AHI)≥10), or non-obese without OSA (AHI<5).
None.
Endothelial function measured by brachial artery ultrasound and expressed as percentage of flow-mediated dilation (FMD%).
When non-obese subjects without OSA were used as the reference (FMD% (mean±SD) 10.1±6.3), endothelial function was found to be impaired in subjects with OSA (FMD% 6.4±3.2) (p=0.003). FMD% did not differ between obese (6.0±3.4) and non-obese (6.7±3.1) OSA subjects (p=0.3). By univariate linear regression analysis, AHI, BMI, gender and baseline brachial artery diameter were significantly associated with FMD%. When these variables were entered into a multivariate model, only AHI was significantly associated with FMD%.
OSA is associated with endothelial dysfunction independently of obesity and conventional risk factors.
阻塞性睡眠呼吸暂停（OSA）和肥胖均与内皮功能障碍相关，后者先于动脉粥样硬化的发生。由于 OSA 患者中肥胖症的患病率很高，因此我们想验证这样一个假说，即 OSA 与肥胖无关，而是独立于肥胖与内皮功能障碍相关。
横断面、基于人群的研究。
挪威大学医院。
从挪威一项基于人群的研究中招募了 71 名受试者（中位数年龄为 44 岁，35%为女性）。参与者分为肥胖组（BMI≥30kg/m²）、非肥胖 OSA 组（AHI≥10）和非肥胖非 OSA 组（AHI<5）。
无。
肱动脉超声测量的内皮功能，以血流介导的扩张（FMD%）表示。
当非肥胖且无 OSA 的受试者作为参考（FMD%（均值±标准差）为 10.1±6.3）时，发现 OSA 患者的内皮功能受损（FMD%为 6.4±3.2）（p=0.003）。肥胖的 OSA 患者（FMD%为 6.0±3.4）与非肥胖的 OSA 患者（FMD%为 6.7±3.1）之间的 FMD%无差异（p=0.3）。单变量线性回归分析显示，AHI、BMI、性别和基线肱动脉直径与 FMD%显著相关。当将这些变量纳入多变量模型时，只有 AHI 与 FMD%显著相关。
OSA 与肥胖和传统危险因素无关，与内皮功能障碍相关。
